transducin
Sign in to savethumb|right|Sensory rhodopsin II (rainbow colored) embedded in a [[lipid bilayer (heads red and tails blue) with Transducin below it. Gtα is colored red, Gtβ blue, and Gtγ yellow. There is a bound GDP molecule in the Gtα-subunit and a bound retinal (black) in the rhodopsin. The N-terminus of rhodopsin is red and the C-terminus blue. Anchoring of transducin to the membrane has been drawn in black.]]
Research
3,459 papers- Rhodopsin, light-sensor of vision.Progress in retinal and eye research · 2023
- Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation.Molecular cell · 2019
- Transducin in rod photoreceptors: translocated when not terminated.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007
- Gustducin and transducin: a tale of two G proteins.Ciba Foundation symposium · 1993
- Interaction of rhodopsin with the G-protein, transducin.BioEssays : news and reviews in molecular, cellular and developmental biology · 1993
via PubMed
Clinical Trials
1 registered- PHASE1RECRUITINGTegavivint With Gemcitabine in Patients With Relapsed or Refractory OsteosarcomaEmory University · NCT07144254
Wikidata facts
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- Commons category
- Transducin
Sources (2)
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~9 min read
Article
7 sectionsContents
- Function in phototransduction
- Mechanism of activation
- The T<sub>βγ</sub> complex
- Interaction with cGMP phosphodiesterase and deactivation
- Genes
- References
- External links
thumb|right|Sensory rhodopsin II (rainbow colored) embedded in a [[lipid bilayer (heads red and tails blue) with Transducin below it. Gtα is colored red, Gtβ blue, and Gtγ yellow. There is a bound GDP molecule in the Gtα-subunit and a bound retinal (black) in the rhodopsin. The N-terminus of rhodopsin is red and the C-terminus blue. Anchoring of transducin to the membrane has been drawn in black.]]
Transducin (Gt) is a protein complex naturally expressed in vertebrate retina rods and cones and it is very important in vertebrate phototransduction. It is a type of heterotrimeric G-protein with different α subunits in rod and cone photoreceptors.