integrin subunit beta 1

Protein · UniProt

Integrin beta-1

Gene

ITGB1

Organism

Homo sapiens (Human)

Length

798 aa

Molecular mass

88,415 Da

Evidence

1: Evidence at protein level

Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/b…

• Beta 1 integrin-dependent and -independent polymerization of fibronectin.The Journal of cell biology · 1996
• Molecular basis of β2 integrin activation by talin unveils subunit-specific mechanisms of integrin signaling.Cell reports · 2025
• Interactions via α(2)β(1) Cell Integrin May Protect against the Progression of Airway Structural Changes in Asthma.International journal of molecular sciences · 2021
• The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line.The Journal of biological chemistry · 1990
• Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits.mAbs · 2024

via PubMed

• PHASE3UNKNOWN
  Comparison of Antiplatelet Effect of Ticagrelor vs Tirofiban in Patients With Non-ST Elevation Acute Coronary SyndromePusan National University Yangsan Hospital · NCT01660373
• PHASE3COMPLETED
  Facilitation Through Aggrastat By drOpping or Shortening Infusion Line in Patients With ST-segment Elevation Myocardial Infarction Compared to or on Top of PRasugrel Loading dOseUniversità degli Studi di Ferrara · NCT01336348

via ClinicalTrials.gov