CD9 molecule
Sign in to saveAlso known as BA-2/p24 antigen, MRP-1, CD9 antigen, tetraspanin-29, Tspan-29, CD9 antigen (p24), antigen CD9, leukocyte antigen MIC3
thumb|Crystal structure of human CD9 CD9 is a gene encoding a protein that is a member of the transmembrane 4 superfamily also known as the tetraspanin family. It is a cell surface glycoprotein that consists of four transmembrane regions and has two extracellular loops that contain disulfide bonds which are conserved throughout the tetraspanin family. Also containing distinct palmitoylation sites that allows CD9 to interact with lipids and other proteins.
Protein · UniProt
CD9 antigen
- Gene
- CD9
- Organism
- Homo sapiens (Human)
- Length
- 228 aa
- Molecular mass
- 25,416 Da
- Evidence
- 1: Evidence at protein level
Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (PubMed:14575715, PubMed:18541721, PubMed:8478605). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and b…
Swiss-Prot (reviewed) · via UniProt
Research
632 papers- Role of tetraspanin CD9 molecule in fertilization of mammals.Physiological research · 2015
- Quantification of protein cargo loading into engineered extracellular vesicles at single-vesicle and single-molecule resolution.Journal of extracellular vesicles · 2021
- Chloroquine treatment induces secretion of autophagy-related proteins and inclusion of Atg8-family proteins in distinct extracellular vesicle populations.Autophagy · 2022
- The CD9 molecule on stromal cells.Leukemia & lymphoma · 2000
- CD9 molecule expressed on stromal cells is involved in osteoclastogenesis.Experimental hematology · 1999
via PubMed
Wikidata facts
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- Commons category
- CD9
Sources (3)
via Wikidata · CC0
~4 min read
Article
6 sectionsContents
- Function
- Interactions
- See also
- References
- Further reading
- External links
thumb|Crystal structure of human CD9 CD9 is a gene encoding a protein that is a member of the transmembrane 4 superfamily also known as the tetraspanin family. It is a cell surface glycoprotein that consists of four transmembrane regions and has two extracellular loops that contain disulfide bonds which are conserved throughout the tetraspanin family. Also containing distinct palmitoylation sites that allows CD9 to interact with lipids and other proteins.
== Function == Tetraspanin proteins are involved in a multitude of biological processes such as adhesion, motility, membrane fusion, signaling and protein trafficking. Tetraspanins play a role in many biological processes because of their ability to interact with many different proteins including interactions between each other. Their distinct palmitoylation sites allow them to organize on the membrane into tetraspanin-enriched microdomains (TEM). These TEMs are thought to play a role in many cellular processes including exosome biogenesis. CD9 is commonly used as a marker for exosomes as it is contained on their surface.