tetraspanin
Sign in to saveAlso known as IPR000301, Transmembrane 4 superfamily, Tetraspanins
thumb|Hypothetical model of the tetraspanin function
Research
6,281 papers- Tetraspanin proteins in membrane remodeling processes.Journal of cell science · 2024
- Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains.Nature cell biology · 2019
- Tetraspanin Assemblies in Virus Infection.Frontiers in immunology · 2018
- EWI2 and its relatives in Tetraspanin-enriched membrane domains regulate malignancy.Oncogene · 2023
- Autoimmunity to tetraspanin-7 in type 1 diabetes.Medical microbiology and immunology · 2020
via PubMed
Wikidata facts
- Instance of
- protein family
Show 1 more fact
- Commons category
- Tetraspanin
Sources (3)
via Wikidata · CC0
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Encyclopedic overview
5 sectionsContents
- List of human tetraspanins
- See also
- Relevance to parasite vaccines
- References
- External links
thumb|Hypothetical model of the tetraspanin function
Tetraspanins are a family of membrane proteins found in all multicellular eukaryotes also referred to as the transmembrane 4 superfamily (TM4SF) proteins. These proteins have four transmembrane alpha-helices and two extracellular domains, one short (called the small extracellular domain or loop, SED/SEL or EC1) and one longer, typically 100 amino acid residues (the large extracellular domain/loop, LED/LEL or EC2). Although several protein families have four transmembrane alpha-helices, tetraspanins are defined by conserved amino acid sequences including four or more cysteine residues in the EC2 domain, with two in a highly conserved 'CCG' motif. Tetraspanins are often thought to act as scaffolding proteins, anchoring multiple proteins to one area of the cell membrane.
Excerpted from Wikipedia’s “tetraspanin” article, available under the CC BY-SA 4.0 licence.