CD46 molecule

Also known as measles virus receptor, CD46, CD46 molecule, complement regulatory protein, membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen), CD46 antigen, complement regulatory protein, TLX, trophoblast leukocyte common antigen, complement membrane cofactor protein

mammalian protein found in Homo sapiens

Protein · UniProt

Membrane cofactor protein

Gene: CD46
Organism: Homo sapiens (Human)
Length: 392 aa
Molecular mass: 43,747 Da
Evidence: 1: Evidence at protein level

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity

3D-structureAlternative splicingComplement pathwayCytoplasmic vesicleDirect protein sequencingDisease variantDisulfide bondFertilization

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Swiss-Prot (reviewed) · via UniProt