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CD81 molecule
Sign in to saveAlso known as CD81 antigen (target of antiproliferative antibody 1), CD81 antigen, Target of the antiproliferative antibody 1, tetraspanin-28, 26 kDa cell surface protein TAPA-1, CD81, tspan-28, Tetraspanin 28
CD81 molecule, also known as CD81 (Cluster of Differentiation 81), is a protein which in humans is encoded by the CD81 gene. It is also known as 26 kDa cell surface protein, TAPA-1 (Target of the Antiproliferative Antibody 1), and Tetraspanin-28 (Tspan-28).
Protein · UniProt
CD81 antigen
- Gene
- CD81
- Organism
- Homo sapiens (Human)
- Length
- 236 aa
- Molecular mass
- 25,809 Da
- Evidence
- 1: Evidence at protein level
Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells (PubMed:16449649, PubMed:20237408, PubMed:27881302). Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production (PubMed:15161911, …
Swiss-Prot (reviewed) · via UniProt
Research
533 papers- CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system.Annual review of immunology · 1998
- Function of the tetraspanin molecule CD81 in B and T cells.Immunologic research · 2014
- Quantification of protein cargo loading into engineered extracellular vesicles at single-vesicle and single-molecule resolution.Journal of extracellular vesicles · 2021
- Human tetraspanin CD81 facilitates invasion of Salmonella enterica into human epithelial cells.Virulence · 2024
- CD81 as a tumor target.Biochemical Society transactions · 2017
via PubMed
Wikidata facts
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- Commons category
- CD81 antigens
via Wikidata · CC0
~3 min read
Article
9 sectionsContents
- Gene
- Function
- Clinical significance
- Interactions
- Ligands
- See also
- References
- Further reading
- External links
CD81 molecule, also known as CD81 (Cluster of Differentiation 81), is a protein which in humans is encoded by the CD81 gene. It is also known as 26 kDa cell surface protein, TAPA-1 (Target of the Antiproliferative Antibody 1), and Tetraspanin-28 (Tspan-28).
== Gene == The gene is located on the plus strand of the short arm of chromosome 11 (11p15.5). It is 20,103 bases in length and encodes a protein of 236 amino acids (predicted molecular weight 25.809 kDa).