ULK1

Also known as ATG1, ATG1A, UNC51, Unc51.1, hATG1, unc-51 like autophagy activating kinase 1

Serine/threonine-protein kinase ULK1 is an enzyme that in humans is encoded by the ULK1 gene.

Gene data

ULK1

Name: unc-51 like autophagy activating kinase 1
Type: protein-coding
Aliases: ATG1, ATG1A, UNC51, Unc51.1, hATG1

Enables identical protein binding activity; protein serine/threonine kinase activity; and small GTPase binding activity. Involved in several processes, including autophagosome assembly; positive regulation by symbiont of host autophagy; and protein phosphorylation. Located in autophagosome; cytosol; and phagophore assembly site membrane. Is extrinsic component of autophagosome membrane; extrinsic component of omegasome membrane; and extrinsic component of phagophore assembly site membrane. Part of Atg1/ULK1 kinase complex. [provided by Alliance of Genome Resources, Apr 2022]

via MyGene.info

Gene · Ensembl

unc-51 like autophagy activating kinase 1

Symbol: ULK1
Biotype: Protein coding
Organism: Homo sapiens
Location: 12:131,894,596-131,923,161
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 2640
exact match: identifiers.org/ncbigene/8408
genomic end: 131923150
genomic start: 131894622
cytogenetic location: 12q24.33

Sources (6)

via Wikidata · CC0

~5 min read

Article

7 sections

Contents

Function
Interactions
Structure
Post-translational modifications
Related diseases
References
Further reading

Serine/threonine-protein kinase ULK1 is an enzyme that in humans is encoded by the ULK1 gene.

Unc-51-like autophagy-activating kinases 1 and 2 (ULK1/2) are two similar isoforms of an enzyme that in humans is encoded by the ULK1/2 genes. The enzyme is specifically a kinase that is involved with autophagy, particularly in response to amino acid withdrawal. Not many studies have been done comparing the two isoforms, but some differences have been recorded.