ZNF598

Also known as zinc finger protein 598, HEL2, zinc finger protein 598, E3 ubiquitin ligase

Zinc finger protein 598 (ZNF598) is a protein that in humans is encoded by the ZNF598 gene.

In the Vinony graph

Within Vinony's link graph, ZNF598 is referenced by 3 other articles, and connects out to PubMed, human chromosome 16 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 16.

Its subject is documented across 5 Wikipedia language editions.

Gene data

ZNF598

Name: zinc finger protein 598, E3 ubiquitin ligase
Type: protein-coding
Position: 1,997,654–2,009,821 (−)
Aliases: HEL2
Ensembl: ENSG00000292232
RefSeq RNA: NM_001405664.1, NM_001405665.1, NM_178167.5
RefSeq protein: NP_001392593.1, NP_001392594.1, NP_835461.2

Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This protein and Grb10-interacting GYF protein 2 have been identified as a components of the mammalian 4EHP (m4EHP) complex. The complex is thought to function as a translation repressor in embryonic development. [provided by RefSeq, Oct 2012].

Pathways

Metabolism of proteins Translation Ribosome-associated quality control ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA

via MyGene.info

Gene · Ensembl

zinc finger protein 598, E3 ubiquitin ligase

Symbol: ZNF598
Biotype: Protein coding
Organism: Homo sapiens
Location: 16:1,997,654-2,009,821
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 5672
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/90850
genomic end: 2009821
genomic start: 2047655
chromosome: human chromosome 16
cytogenetic location: 16p13.3

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

Function
References

Zinc finger protein 598 (ZNF598) is a protein that in humans is encoded by the ZNF598 gene.

== Function == Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This protein and Grb10-interacting GYF protein 2 have been identified as a components of the mammalian 4EHP (m4EHP) complex. The complex is thought to function as a translation repressor in embryonic development. ZNF598 and its yeast homologue Hel2 are ubiquitin ligases that ubiquitinate the 40S ribosomal subunit during ribosome-associated protein quality control.

Excerpted from Wikipedia’s “ZNF598” article, available under the CC BY-SA 4.0 licence.