CASP3
Sign in to saveAlso known as CPP32, CPP32B, SCA-1, caspase 3
protein-coding gene in the species Homo sapiens
Gene data
CASP3- Name
- caspase 3
- Type
- protein-coding
- Position
- 184,627,695–184,650,418 (−)
- Aliases
- CPP32, CPP32B, SCA-1
- Ensembl
- ENSG00000164305
- RefSeq RNA
- NM_001354777.2, NM_001354779.2, NM_001354780.2, NM_001354781.2, NM_001354782.2
- RefSeq protein
- NP_001341706.1, NP_001341708.1, NP_001341709.1, NP_001341710.1, NP_001341711.1
The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
caspase 3
- Symbol
- CASP3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:184,627,695-184,650,418
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- 1rhj.jpg
Show 3 more facts
- HomoloGene ID
- 37912
- exact match
- identifiers.org/ncbigene/836
- Commons category
- Caspase 3
via Wikidata · CC0