DCC

Also known as DCC netrin 1 receptor, CRC18, CRCR1, IGDCC1, MRMV1, NTN1R1, HGPPS2

protein-coding gene in the species Homo sapiens

Gene data

DCC

Name: DCC netrin 1 receptor
Type: protein-coding
Aliases: CRC18, CRCR1, HGPPS2, IGDCC1, MRMV1, NTN1R1

This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009].

via MyGene.info