CASP7
Sign in to saveAlso known as CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3, Caspase 7
protein-coding gene in the species Homo sapiens
Gene data
CASP7- Name
- caspase 7
- Type
- protein-coding
- Position
- 113,679,162–113,731,290 (+)
- Aliases
- CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3
- Ensembl
- ENSG00000165806
- RefSeq RNA
- NM_001227.5, NM_001267056.2, NM_001267057.1, NM_001267058.2, NM_001320911.2
- RefSeq protein
- NP_001218.1, NP_001253985.1, NP_001253986.1, NP_001253987.1, NP_001307840.1
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
caspase 7
- Symbol
- CASP7
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:113,679,158-113,731,668
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein CASP7 PDB 1f1j.png
Show 6 more facts
- HomoloGene ID
- 11168
- exact match
- identifiers.org/ncbigene/840
- genomic start
- 115438942
- genomic end
- 115490662
- cytogenetic location
- 10q25.3
- Commons category
- Caspase 7
Sources (8)
via Wikidata · CC0