BCL2L12

Also known as BCL2 like 12

Bcl-2-like protein 12 is a protein that in humans is encoded by the BCL2L12 gene.

In the Vinony graph

Within Vinony's link graph, BCL2L12 is referenced by 2 other articles, and connects out to Q180686, apoptotic process and human chromosome 19.

It is catalogued under the topic Genes on human chromosome 19.

Its subject is documented across 5 Wikipedia language editions.

Gene data

BCL2L12

Name: BCL2 like 12
Type: protein-coding
Position: 49,664,622–49,673,917 (+)
Ensembl: ENSG00000126453
RefSeq RNA: NM_001040668.2, NM_001282516.2, NM_001282517.2, NM_001282519.2, NM_001282520.1
RefSeq protein: NP_001035758.2, NP_001269445.2, NP_001269446.2, NP_001269448.2, NP_001269449.1

This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].

Gene Ontology

Biological process

regulation of apoptotic process negative regulation of apoptotic process positive regulation of transcription by RNA polymerase II negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Molecular function

p53 binding protein binding

Cellular component

nucleus nucleus membrane

Pathways

Regulation of apoptosis by parathyroid hormone-related protein

via MyGene.info

Gene · Ensembl

BCL2 like 12

Symbol: BCL2L12
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:49,664,622-49,673,917
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 12619
exact match: identifiers.org/ncbigene/83596
genomic end: 50177173
genomic start: 50168823
cytogenetic location: 19q13.33

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

References
External links
Further reading

Bcl-2-like protein 12 is a protein that in humans is encoded by the BCL2L12 gene.

The protein encoded by this gene belongs to the Bcl-2 protein family. Bcl-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 2 (BH2). The function of this gene has not yet been determined. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Excerpted from Wikipedia’s “BCL2L12” article, available under the CC BY-SA 4.0 licence.