Caspase 4
Sign in to saveAlso known as ICH-2, ICE(rel)-II, protease ICH-2, caspase-4, caspase 4, apoptosis-related cysteine peptidase, CASP-4, CASP4, caspase 4, apoptosis-related cysteine protease
mammalian protein found in Homo sapiens
Protein · UniProt
Caspase-4
- Gene
- CASP4
- Organism
- Homo sapiens (Human)
- Length
- 377 aa
- Molecular mass
- 43,262 Da
- Evidence
- 1: Evidence at protein level
Inflammatory caspase that acts as the effector of the non-canonical inflammasome by mediating lipopolysaccharide (LPS)-induced pyroptosis (PubMed:25119034, PubMed:26375003, PubMed:32109412, PubMed:34671164, PubMed:37001519, PubMed:37993712, PubMed:37993714). Also indirectly activates the NLRP3 and NLRP6 inflammasomes (PubMed:23516580, PubMed:26375003, PubMed:32109412, PubMed:7797510). Acts as a thiol protease that cleaves a tetrapeptide after an Asp residue at position P1: catalyzes cleavage of CGAS, GSDMD and IL18 (PubMed:15326478, PubMed:23516580, PubMed:26375003, PubMed:28314590, PubMed:…
Swiss-Prot (reviewed) · via UniProt