CAPN1
Sign in to saveAlso known as CANP, CANP1, CANPL1, muCANP, muCL, SPG76, calpain 1
protein-coding gene in the species Homo sapiens
Gene data
CAPN1- Name
- calpain 1
- Type
- protein-coding
- Position
- 65,180,566–65,212,006 (+)
- Aliases
- CANP, CANP1, CANPL1, SPG76, muCANP, muCL
- Ensembl
- ENSG00000014216
- RefSeq RNA
- NM_001198868.2, NM_001198869.2, NM_005186.4, NR_040008.2, XM_006718698.3
- RefSeq protein
- NP_001185797.1, NP_001185798.1, NP_005177.2, XP_006718761.1, XP_011543594.1
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].
Gene Ontology
Biological process
Molecular function
calcium-dependent cysteine-type endopeptidase activitycalcium-dependent cysteine-type endopeptidase activitycalcium-dependent cysteine-type endopeptidase activitycalcium-dependent cysteine-type endopeptidase activitycalcium-dependent cysteine-type endopeptidase activitycalcium ion bindingcalcium ion bindingprotein binding
Pathways
Protein processing in endoplasmic reticulum - Homo sapiens (human)Apoptosis - Homo sapiens (human)Necroptosis - Homo sapiens (human)Cellular senescence - Homo sapiens (human)Alzheimer disease - Homo sapiens (human)Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)Shigellosis - Homo sapiens (human)Developmental BiologyDegradation of the extracellular matrixDegradation of the extracellular matrix
via MyGene.info
Gene · Ensembl
calpain 1
- Symbol
- CAPN1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:65,180,566-65,212,006
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein CAPN1 PDB 1zcm.png
Show 5 more facts
- HomoloGene ID
- 3800
- genomic end
- 64979477
- exact match
- identifiers.org/ncbigene/823
- genomic start
- 64948037
- cytogenetic location
- 11q13.1
Sources (4)
via Wikidata · CC0
Connections
Q180686
Entity
human chromosome 11
Entity
Ensembl genome database project
Entity
protein
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Wikidata
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gene
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chromosome
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Wayback Machine
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digital object identifier
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bibcode
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human genome
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base pair
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locus
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gene expression
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Online Mendelian Inheritance in Man
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peptidase
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Enzyme Commission number
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Protein Data Bank
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Q22908627
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Entrez
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