CAPN9
Sign in to saveAlso known as GC36, nCL-4, calpain 9
Calpain-9 is a protein that in humans is encoded by the CAPN9 gene.
Gene data
CAPN9- Name
- calpain 9
- Type
- protein-coding
- Aliases
- GC36, nCL-4
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
calpain 9
- Symbol
- CAPN9
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:230,747,266-230,804,397
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein CAPN9 PDB 1ziv.png
Show 5 more facts
- HomoloGene ID
- 38208
- exact match
- identifiers.org/ncbigene/10753
- genomic end
- 230937749
- genomic start
- 230883130
- cytogenetic location
- 1q42.2
via Wikidata · CC0
~1 min read
Article
3 sectionsContents
- References
- Further reading
- External links
Calpain-9 is a protein that in humans is encoded by the CAPN9 gene.
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.