CTSL

Name

cathepsin L

Type

protein-coding

Position

87,724,051–87,731,469 (+)

Aliases

CATL, CTSL1, MEP

Ensembl

ENSG00000135047

RefSeq RNA

NM_001257971.2, NM_001257972.2, NM_001257973.2, NM_001382757.1, NM_001382758.1

RefSeq protein

NP_001244900.1, NP_001244901.1, NP_001244902.1, NP_001369686.1, NP_001369687.1

The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell. [provided by RefSeq, Aug 2020].

via MyGene.info

Wikidata facts

Image

Protein CTSL1 PDB 1cjl.png

via Wikidata · CC0