CASP12

Name

caspase 12 (gene/pseudogene)

Type

protein-coding

Position

104,885,718–104,898,670 (−)

Aliases

CASP-12, CASP12P1

Ensembl

ENSG00000204403

RefSeq RNA

NM_001191016.3, NR_000035.2, NR_034061.4, NR_034063.4, NR_034064.4

RefSeq protein

NP_001177945.2

Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011].

via MyGene.info

Gene · Ensembl

caspase 12 (gene/pseudogene)

Symbol

CASP12

Biotype

Protein coding

Organism

Homo sapiens

Location

11:104,885,718-104,898,670

Strand

Reverse (−)

Assembly

GRCh38

• Analysis of CASP12 diagnostic and prognostic values in cervical cancer based on TCGA database.Bioscience reports · 2019
• Assessment of protein assembly prediction in CASP12.Proteins · 2018
• Protein structure prediction using Rosetta in CASP12.Proteins · 2018
• Evaluation of the template-based modeling in CASP12.Proteins · 2018
• Assessment of the model refinement category in CASP12.Proteins · 2018

via PubMed

Wikidata facts

via Wikidata · CC0