papain
Sign in to savePapain, also known as papaya proteinase I, is a cysteine protease () enzyme present in papaya (Carica papaya) and mountain papaya (Vasconcellea cundinamarcensis). It is the namesake member of the papain-like protease family.
Key facts
- Protein family.Symbol
- Peptidase_C1
- Protein family.Name
- Papain family cysteine protease
- Protein family.image
- Papain_cartoon.png
- Protein family.caption
- Papain from Carica papaya
- Protein family.Pfam
- PF00112
- Protein family.InterPro
- IPR000668
- Protein family.Prosite
- PDOC00126
- Protein family.SCOP
- 1aec
- Enzyme.Name
- papain
- Enzyme.EC_number
- 3.4.22.2
- Enzyme.CAS_number
- 9001-73-4
via Wikipedia infobox
Protein · UniProt
Papain
- Organism
- Carica papaya (Papaya)
- Length
- 345 aa
- Molecular mass
- 38,922 Da
- Evidence
- 1: Evidence at protein level
Cysteine proteinase with a high level of diversity in substrate specificity, an amino acid bearing a large hydrophobic side chain at the P2 position is preferred
Swiss-Prot (reviewed) · via UniProt
Research
12,734 papers- Enzyme treatment of red blood cells: use of ficin and papain.Immunohematology · 2022
- Insights into Coronavirus Papain-like Protease Structure, Function and Inhibitors.Protein and peptide letters · 2022
- The structure of papain.Advances in protein chemistry · 1971
- Liposome-Papain Conjugates for Catalytic Digestion of Antibody Producing Fab Fragments.ACS applied bio materials · 2024
- [Papain].Postepy biochemii · 1972
via PubMed
Clinical Trials
12 registered- PHASE1/PHASE2COMPLETEDAssessment of the Safety and Efficacy of DERMASTREAM™ - ENZYSTREAM™ System for the Treatment of Chronic Venous UlcersEnzySurge · NCT00485329
- PHASE2UNKNOWNAntimicrobial Photodynamic Therapy Mediated by Papain Gel on Peri-Implantitis LesionsUniversity of Nove de Julho · NCT03753958
- PHASE2UNKNOWNSPI-1005 Treatment in Moderate COVID-19 PatientsSound Pharmaceuticals, Incorporated · NCT04484025
- NACOMPLETEDChemomechanical Caries Removal Using Papain GelUniversity of Nove de Julho · NCT01811420
- PHASE2UNKNOWNSPI-1005 Treatment in Severe COVID-19 PatientsSound Pharmaceuticals, Incorporated · NCT04483973
- PHASE2TERMINATEDTrial of Quercetin, Bromelain, Rye Flower Pollen & Papain on Reducing Severity of Radiation-Induced ProstatitisUniversity of Utah · NCT04252625
Wikidata facts
Show 3 more facts
- Commons category
- Papain
- EC enzyme number
- 3.4.22.2
- MCN code
- 3507.90.26
via Wikidata · CC0
~9 min read
Article
12 sectionsContents
- Papain family
- Structure
- Function
- Uses
- Immunoglobulins
- Production
- US restriction on marketing
- Unapproved topical papain products
- Human cysteine proteases from papain family
- See also
- References
- External links
Papain, also known as papaya proteinase I, is a cysteine protease () enzyme present in papaya (Carica papaya) and mountain papaya (Vasconcellea cundinamarcensis). It is the namesake member of the papain-like protease family.
It has wide ranging commercial applications in the leather, cosmetic, textiles, detergents, food and pharmaceutical industries. In the food industry, papain is used as an active ingredient in many commercial meat tenderizers.