cystatins
Sign in to saveAlso known as cystatin, Cystatin domain, protein family, IPR000010
The cystatins are a family of cysteine protease inhibitors which share a sequence homology and a common tertiary structure of an alpha helix lying on top of an anti-parallel beta sheet. The family is subdivided as described below.
Research
15,177 papers- [Cystatins].Postepy biochemii · 1987
- Cystatins: biochemical and structural properties, and medical relevance.Frontiers in bioscience : a journal and virtual library · 2008
- Cystatins--inhibitors of cysteine proteinases.Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists · 1992
- The cystatins: protein inhibitors of cysteine proteinases.FEBS letters · 1991
- Epigenetic regulation of cystatins in cancer.Frontiers in bioscience (Landmark edition) · 2009
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Article
8 sectionsContents
- Types
- Human cystatins
- Plant cystatins
- Membrane permeability
- See also
- References
- Further reading
- External links
The cystatins are a family of cysteine protease inhibitors which share a sequence homology and a common tertiary structure of an alpha helix lying on top of an anti-parallel beta sheet. The family is subdivided as described below.
Cystatins show similarity to fetuins, kininogens, histidine-rich glycoproteins and cystatin-related proteins. Cystatins mainly inhibit peptidase enzymes (another term for proteases) belonging to peptidase families C1 (papain family) and C13 (legumain family). They are known to mis-fold to form amyloid deposits and are implicated in several diseases.