LTBR

Name

lymphotoxin beta receptor

Type

protein-coding

Position

6,375,045–6,391,571 (+)

Aliases

D12S370, LT-BETA-R, TNF-R-III, TNFCR, TNFR-RP, TNFR2-RP, TNFR3, TNFRSF3

Ensembl

ENSG00000111321

RefSeq RNA

NM_001270987.2, NM_001414303.1, NM_001414304.1, NM_001414305.1, NM_001414306.1

RefSeq protein

NP_001257916.1, NP_001401232.1, NP_001401233.1, NP_001401234.1, NP_001401235.1

This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012].