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GeneQ18031090· pop 6· linked from 818 articles

RELB

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Also known as I-REL, IREL, REL-B, RELB proto-oncogene, NF-kB subunit, IMD53

Transcription factor RelB is a protein that in humans is encoded by the RELB gene.

Gene data

RELB

Name: RELB proto-oncogene, NF-kB subunit
Type: protein-coding
Position: 45,001,461–45,038,192 (+)
Aliases: I-REL, IMD53, IREL, REL-B
Ensembl: ENSG00000104856
RefSeq RNA: NM_001411087.1, NM_006509.4, XM_005259128.3, XM_047439189.1, XM_047439190.1
RefSeq protein: NP_001398016.1, NP_006500.2, XP_005259185.1, XP_047295145.1, XP_047295146.1

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and protein kinase binding activity. Involved in lymphocyte differentiation and negative regulation of interferon-beta production. Located in cytosol and nucleoplasm. Part of chromatin; nucleus; and transcription repressor complex. Colocalizes with centrosome. Implicated in breast cancer and immunodeficiency 53. Biomarker of breast cancer and transitional cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Biological process

regulation of DNA-templated transcription inflammatory response canonical NF-kappaB signal transduction regulation of gene expression lymphocyte differentiation lymphocyte differentiation negative regulation of interferon-beta production circadian regulation of gene expression

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity

Cellular component

chromatin chromatin nucleus nucleus nucleus nucleoplasm nucleoplasm cytoplasm

Pathways

MAPK signaling pathway - Homo sapiens (human)NF-kappa B signaling pathway - Homo sapiens (human)Osteoclast differentiation - Homo sapiens (human)C-type lectin receptor signaling pathway - Homo sapiens (human)Human T-cell leukemia virus 1 infection - Homo sapiens (human)Epstein-Barr virus infection - Homo sapiens (human)Cytokine Signaling in Immune system Innate Immune System Immune System Dectin-1 mediated noncanonical NF-kB signaling

via MyGene.info

Gene · Ensembl

RELB proto-oncogene, NF-kB subunit

Symbol: RELB
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:45,001,431-45,038,194
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein RELB PDB 1zk9.png

Show 5 more facts

HomoloGene ID: 4747
exact match: identifiers.org/ncbigene/5971
genomic end: 45541452
genomic start: 45001449
cytogenetic location: 19q13.32

Sources (5)

via Wikidata · CC0

~2 min read

Article

5 sections

Contents

Interactions
Activation and function
See also
References
Further reading

Transcription factor RelB is a protein that in humans is encoded by the RELB gene.

== Interactions ==

Available in 6 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 19 Transcription factors