CUL3

Also known as CUL-3, PHA2E, cullin 3, NEDAUS

Cullin 3 is a protein that in humans is encoded by the CUL3 gene.

Gene data

CUL3

Name: cullin 3
Type: protein-coding
Position: 224,470,150–224,585,397 (−)
Aliases: CUL-3, NEDAUS, PHA2E
Ensembl: ENSG00000036257
RefSeq RNA: NM_001257197.2, NM_001257198.2, NM_003590.5, XM_006712800.3, XM_011511995.2
RefSeq protein: NP_001244126.1, NP_001244127.1, NP_003581.1, XP_006712863.2, XP_011510297.1

This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012].

Gene Ontology

Biological process

G1/S transition of mitotic cell cycle

Article

10 sections

Contents

Function
Cullin 3-RING E3 ubiquitin ligases
Clinical significance
Familial hyperkalemic hypertension
Neurodevelopmental Disorders
Cancer
Interactions
References
Further reading
External links

Cullin 3 is a protein that in humans is encoded by the CUL3 gene.

Cullin 3 protein belongs to the family of cullins which in mammals contains eight proteins (Cullin 1, Cullin 2, Cullin 3, Cullin 4A, Cullin 4B, Cullin 5, Cullin 7 and Cullin 9). Cullin proteins are an evolutionarily conserved family of proteins throughout yeast, plants and mammals.