CAND1
Sign in to saveAlso known as TIP120, TIP120A, cullin associated and neddylation dissociated 1
Cullin-associated NEDD8-dissociated protein 1 is a protein that in humans is encoded by the CAND1 gene.
Gene data
CAND1- Name
- cullin associated and neddylation dissociated 1
- Type
- protein-coding
- Aliases
- TIP120, TIP120A
This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016].
via MyGene.info
Gene · Ensembl
cullin associated and neddylation dissociated 1
- Symbol
- CAND1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:67,269,277-67,319,953
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein CAND1 PDB 1u6g.png
Show 5 more facts
- HomoloGene ID
- 10202
- exact match
- identifiers.org/ncbigene/55832
- genomic end
- 67319953
- genomic start
- 67269358
- cytogenetic location
- 12q14.3-q15
Sources (4)
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Interactions
- References
- External links
- Further reading
Cullin-associated NEDD8-dissociated protein 1 is a protein that in humans is encoded by the CAND1 gene.
== Interactions ==