CUL1

Also known as cullin 1

Cullin 1, also known as CUL1, is a human protein and gene from cullin family. This protein plays an important role in protein degradation and protein ubiquitination.

Gene data

CUL1

Name: cullin 1
Type: protein-coding
Position: 148,697,914–148,801,110 (+)
Ensembl: ENSG00000055130
RefSeq RNA: NM_001370660.1, NM_001370661.1, NM_001370662.1, NM_001370663.1, NM_001370664.1
RefSeq protein: NP_001357589.1, NP_001357590.1, NP_001357591.1, NP_001357592.1, NP_001357593.1

Predicted to enable ubiquitin protein ligase binding activity and ubiquitin-protein transferase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Located in plasma membrane. Part of Parkin-FBXW7-Cul1 ubiquitin ligase complex and SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Biological process

G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle

Article

2 sections

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Further reading
External links

Cullin 1, also known as CUL1, is a human protein and gene from cullin family. This protein plays an important role in protein degradation and protein ubiquitination.

This is an essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, it serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.