E2F1

Name

E2F transcription factor 1

Type

protein-coding

Position

33,675,477–33,686,385 (−)

Aliases

E2F-1, RBAP1, RBBP3, RBP3

Ensembl

ENSG00000101412

RefSeq RNA

NM_005225.3, XM_047439961.1, XM_054323133.1

RefSeq protein

NP_005216.1, XP_047295917.1, XP_054179108.1

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

E2F transcription factor 1

Symbol

E2F1

Biotype

Protein coding

Organism

Homo sapiens

Location

20:33,675,477-33,686,426

Strand

Reverse (−)

Assembly

GRCh38

via PubMed

Wikidata facts

Image

Protein E2F1 PDB 2aze.png

via Wikidata · CC0