CUL4B
Sign in to saveAlso known as CUL-4B, MRXHF2, MRXS15, MRXSC, SFM2, cullin 4B
Cullin-4B is a protein that in humans is encoded by the CUL4B gene which is located on the X chromosome. CUL4B has high sequence similarity with CUL4A, with which it shares certain E3 ubiquitin ligase functions. CUL4B is largely expressed in the nucleus and regulates several key functions including: cell cycle progression, chromatin remodeling and neurological and placental development in mice. In humans, CUL4B has been implicated in X-linked intellectual disability and is frequently mutated in pancreatic adenocarcinomas and a small percentage of various lung cancers. Viruses such as HIV can a
Gene data
CUL4B- Name
- cullin 4B
- Type
- protein-coding
- Chromosome
- X
- Position
- 120,505,920–120,604,074 (−)
- Aliases
- CUL-4B, MRXHF2, MRXS15, MRXSC, SFM2
- Ensembl
- ENSG00000158290
- RefSeq RNA
- NM_001079872.2, NM_001330624.2, NM_001369145.1, NM_003588.4
- RefSeq protein
- NP_001073341.1, NP_001317553.1, NP_001356074.1, NP_003579.3
This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
cullin 4B
- Symbol
- CUL4B
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr X:120,505,920-120,604,074
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein CUL4B PDB 2do7.png
Show 5 more facts
- HomoloGene ID
- 2660
- cytogenetic location
- Xq24
- exact match
- identifiers.org/ncbigene/8450
- genomic end
- 120604074
- genomic start
- 120505920
Sources (4)
via Wikidata · CC0
~6 min read
Article
15 sectionsContents
- Structure
- Functions
- Cell cycle regulation and chromatin remodeling
- Mammalian embryonic development
- Neurological development
- Clinical significance
- X-linked intellectual disability
- Viral pathogenesis
- Cancer
- Thalidomide treatment
- Interactions and substrates
- Notes
- References
- External links
- Further reading
Cullin-4B is a protein that in humans is encoded by the CUL4B gene which is located on the X chromosome. CUL4B has high sequence similarity with CUL4A, with which it shares certain E3 ubiquitin ligase functions. CUL4B is largely expressed in the nucleus and regulates several key functions including: cell cycle progression, chromatin remodeling and neurological and placental development in mice. In humans, CUL4B has been implicated in X-linked intellectual disability and is frequently mutated in pancreatic adenocarcinomas and a small percentage of various lung cancers. Viruses such as HIV can also co-opt CUL4B-based complexes to promote viral pathogenesis. CUL4B complexes containing Cereblon are also targeted by the teratogenic drug thalidomide.
== Structure ==