CCNE1

Name

cyclin E1

Type

protein-coding

Position

29,811,471–29,824,313 (+)

Aliases

CCNE, pCCNE1

Ensembl

ENSG00000105173

RefSeq RNA

NM_001238.4, NM_001322259.2, NM_001322261.2, NM_001322262.2, NM_001440305.1

RefSeq protein

NP_001229.1, NP_001309188.1, NP_001309190.1, NP_001309191.1, NP_001427234.1

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016].

via MyGene.info

Gene · Ensembl

cyclin E1

Symbol

CCNE1

Biotype

Protein coding

Organism

Homo sapiens

Location

19:29,811,471-29,824,313

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Image

Protein CCNE1 PDB 1w98.png

via Wikidata · CC0