CCND2

Name

cyclin D2

Type

protein-coding

Position

4,269,755–4,306,933 (+)

Aliases

KIAK0002, MPPH3

Ensembl

ENSG00000118971

RefSeq RNA

NM_001759.4

RefSeq protein

NP_001750.1

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014].

via MyGene.info

Gene · Ensembl

cyclin D2

Symbol

CCND2

Biotype

Protein coding

Organism

Homo sapiens

Location

12:4,269,755-4,306,933

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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