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GeneQ5104298· pop 6· linked from 509 articles

CCKAR

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Also known as CCK-A, CCK1-R, CCK1R, CCKRA, cholecystokinin A receptor

protein-coding gene in the species Homo sapiens

Gene data

CCKAR

Name: cholecystokinin A receptor
Type: protein-coding
Position: 26,481,396–26,490,484 (−)
Aliases: CCK-1R, CCK-A, CCK1-R, CCK1R, CCKRA
Ensembl: ENSG00000163394
RefSeq RNA: NM_000730.3
RefSeq protein: NP_000721.1

This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway cellular response to hormone stimulus cholecystokinin signaling pathway regulation of hormone secretion

Molecular function

G protein-coupled receptor activity cholecystokinin receptor activity cholecystokinin receptor activity cholecystokinin receptor activity cholecystokinin receptor activity protein binding peptide hormone binding

Cellular component

plasma membrane plasma membrane plasma membrane plasma membrane membrane membrane

Pathways

Calcium signaling pathway - Homo sapiens (human)Neuroactive ligand-receptor interaction - Homo sapiens (human)Insulin secretion - Homo sapiens (human)Pancreatic secretion - Homo sapiens (human)Signal Transduction Signaling by GPCR Class A/1 (Rhodopsin-like receptors)Peptide ligand-binding receptors GPCR downstream signalling G alpha (q) signalling events

via MyGene.info

Gene · Ensembl

cholecystokinin A receptor

Symbol: CCKAR
Biotype: Protein coding
Organism: Homo sapiens
Location: 4:26,481,396-26,490,484
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein CCKAR PDB 1d6g.png

Show 5 more facts

HomoloGene ID: 37337
exact match: identifiers.org/ncbigene/886
genomic start: 26481396
genomic end: 26490484
cytogenetic location: 4p15.2

Sources (3)

via Wikidata · CC0

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via Wikidata sitelinks · CC0

Categories

Cholecystokinin receptors Genes on human chromosome 4 G protein-coupled receptors Protein domains