TP63

Also known as AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8

Tumor protein p63, typically referred to as p63, also known as transformation-related protein 63, is a protein that in humans is encoded by the TP63 (also known as the p63) gene.

Gene data

TP63

Name: tumor protein p63
Type: protein-coding
Aliases: AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4

This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016].

via MyGene.info

Gene · Ensembl

tumor protein p63

Symbol: TP63
Biotype: Protein coding
Organism: Homo sapiens
Location: 3:189,631,252-189,897,276
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein TP73L PDB 1rg6.png

Show 5 more facts

HomoloGene ID: 31189
exact match: identifiers.org/ncbigene/8626
genomic end: 189897276
genomic start: 189631389
cytogenetic location: 3q28

Sources (4)

via Wikidata · CC0

~6 min read

Article

12 sections

Contents

Function
Oocyte integrity
Clinical significance
Molecular mechanism
Vulvar cancer
Diagnostic utility
Interactions
Regulation
See also
References
Further reading
External links

Tumor protein p63, typically referred to as p63, also known as transformation-related protein 63, is a protein that in humans is encoded by the TP63 (also known as the p63) gene.

The TP63 gene was discovered 20 years after the discovery of the p53 tumor suppressor gene and along with p73 constitutes the p53 gene family based on their structural similarity. Despite being discovered significantly later than p53, phylogenetic analysis of p53, p63 and p73, suggest that p63 was the original member of the family from which p53 and p73 evolved.