TP73

Also known as P73, tumor protein p73, CILD47

p73 is a protein related to the p53 tumor protein. Because of its structural resemblance to p53, it has also been considered a tumor suppressor. It is involved in cell cycle regulation, and induction of apoptosis. Like p53, p73 is characterized by the presence of different isoforms of the protein. This is explained by splice variants, and an alternative promoter in the DNA sequence.

Gene data

TP73

Name: tumor protein p73
Type: protein-coding
Position: 3,652,516–3,736,201 (+)
Aliases: CILD47, P73
Ensembl: ENSG00000078900
RefSeq RNA: NM_001126240.3, NM_001126241.3, NM_001126242.3, NM_001204184.2, NM_001204185.2
RefSeq protein: NP_001119712.1, NP_001119713.1, NP_001119714.1, NP_001191113.1, NP_001191114.1

This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011].

Gene Ontology

Biological process

mismatch repair regulation of DNA-templated transcription apoptotic process DNA damage response DNA damage response regulation of mitotic cell cycle negative regulation of cell population proliferation intrinsic apoptotic signaling pathway in response to DNA damage

Molecular function

transcription cis-regulatory region binding transcription cis-regulatory region binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific transcription corepressor binding

Cellular component

chromatin chromatin nucleus nucleus nucleus nucleoplasm nucleoplasm cytoplasm

Pathways

p53 signaling pathway - Homo sapiens (human)Hippo signaling pathway - Homo sapiens (human)Neurotrophin signaling pathway - Homo sapiens (human)Measles - Homo sapiens (human)Apoptosis Intrinsic Pathway for Apoptosis Activation of BH3-only proteins Activation of PUMA and translocation to mitochondria Generic Transcription Pathway Transcriptional Regulation by TP53

via MyGene.info

Gene · Ensembl

tumor protein p73

Symbol: TP73
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:3,652,307-3,736,201
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein TP73 PDB 1cok.png

Show 5 more facts

HomoloGene ID: 3960
exact match: identifiers.org/ncbigene/7161
genomic end: 3652765
genomic start: 3652516
cytogenetic location: 1p36.32

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p73, also known as tumor protein 73 (TP73), protein was the first identified homologue of the tumor suppressor gene, p53. Like p53, p73 has several variants. It is expressed as distinct forms differing at either at the C- or the N-terminus. Currently, six different C-terminus splicing variants have been found in normal cells. The p73 gene encodes a protein with a significant sequence homology and a functional similarity with the tumor suppressor p53. The over-expression of p73 in cultured cells promotes a growth arrest and/or apoptosis similarly to p53.