BUB1

Also known as BUB1A, BUB1L, hBUB1, BUB1 mitotic checkpoint serine/threonine kinase

Mitotic checkpoint serine/threonine-protein kinase BUB1 also known as BUB1 (budding uninhibited by benzimidazoles 1) is an enzyme that in humans is encoded by the BUB1 gene.

Gene data

BUB1

Name: BUB1 mitotic checkpoint serine/threonine kinase
Type: protein-coding
Position: 110,636,333–110,678,078 (−)
Aliases: BUB1A, BUB1L, MCPH30, hBUB1
Ensembl: ENSG00000169679
RefSeq RNA: NM_001278616.2, NM_001278617.2, NM_004336.5, XM_047445616.1, XM_054343580.1
RefSeq protein: NP_001265545.1, NP_001265546.1, NP_004327.1, XP_047301572.1, XP_054199555.1

This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

Pathways

Cell cycle - Homo sapiens (human)Oocyte meiosis - Homo sapiens (human)Progesterone-mediated oocyte maturation - Homo sapiens (human)Amplification of signal from the kinetochores Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Signal Transduction Cell Cycle Signaling by Rho GTPases RHO GTPase Effectors Separation of Sister Chromatids

via MyGene.info

Gene · Ensembl

BUB1 mitotic checkpoint serine/threonine kinase

Symbol: BUB1
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:110,635,468-110,678,098
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: BUB1 3E7E.png

Show 6 more facts

HomoloGene ID: 37910
exact match: identifiers.org/ncbigene/699
cytogenetic location: 2q13
genomic start: 110637528
Commons category: BUB1
genomic end: 110678063

Sources (5)

via Wikidata · CC0

~7 min read

Article

8 sections

Contents

Structure
Subcellular location
Function
Implications in cancer
Link to caspase-independent mitotic death (CIMD)
See also
References
External links

Mitotic checkpoint serine/threonine-protein kinase BUB1 also known as BUB1 (budding uninhibited by benzimidazoles 1) is an enzyme that in humans is encoded by the BUB1 gene.

Bub1 is a serine/threonine protein kinase first identified in genetic screens of ''Saccharomyces cerevisiae (baker's yeast). The protein is bound to kinetochores and plays a key role in the establishment of the mitotic spindle checkpoint and chromosome congression. The mitotic checkpoint kinase is evolutionarily conserved in organisms as diverse as Saccharomyces cerevisiae'' and humans. Loss-of-function mutations or absence of Bub1 has been reported to result in aneuploidy, chromosomal instability (CIN) and premature senescence.