APC

Name

APC regulator of Wnt signaling pathway

Type

protein-coding

Position

112,707,498–112,846,239 (+)

Aliases

BTPS2, DESMD, DP2, DP2.5, DP3, GS, PPP1R46

Ensembl

ENSG00000134982

RefSeq RNA

NM_000038.6, NM_001127510.3, NM_001127511.3, NM_001354895.2, NM_001354896.2

RefSeq protein

NP_000029.2, NP_001120982.1, NP_001120983.2, NP_001341824.1, NP_001341825.1

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers, where disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jun 2022].

via MyGene.info

Gene · Ensembl

APC regulator of Wnt signaling pathway

Symbol

APC

Biotype

Protein coding

Organism

Homo sapiens

Location

5:112,707,452-112,846,239

Strand

Forward (+)

Assembly

GRCh38

• Nuclear APC.Advances in experimental medicine and biology · 2009
• APC in the nervous system.Medical molecular morphology · 2026
• [The APC gene].Nihon rinsho. Japanese journal of clinical medicine · 1996
• Adenomatous Polyposis Coli (APC) in cell migration.European journal of cell biology · 2022
• Advances and Insights of APC-Asef Inhibitors for Metastatic Colorectal Cancer Therapy.Frontiers in molecular biosciences · 2021

via PubMed

Wikidata facts

Image

PBB Protein APC image.jpg

via Wikidata · CC0