APOH

Also known as B2G1, B2GP1, BG, apolipoprotein H

protein-coding gene in the species Homo sapiens

In the Vinony graph

Within Vinony's link graph, APOH is referenced by 160 other articles, and connects out to mucin, PubMed and Ensembl genome database project.

Vinony files it under Apolipoproteins, Autoantigens and Autoimmune diseases.

Its subject is documented across 7 Wikipedia language editions.

Gene data

APOH

Name: apolipoprotein H
Type: protein-coding
Position: 66,211,543–66,256,525 (−)
Aliases: B2G1, B2GP1, BG
Ensembl: ENSG00000091583
RefSeq RNA: NM_000042.3
RefSeq protein: NP_000033.2

Apolipoprotein H, also known as beta-2-glycoprotein I, is a component of circulating plasma lipoproteins. It has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, hemostasis, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome (APS). The anti-beta (2) glycoprotein I antibodies from APS patients, mediate inhibition of activated protein C which has anticoagulant properties. Because beta-2-GPI is the main autoantigen in patients with APS, the disruption of this pathway by autoantibodies may be an important mechanism for thrombosis in patients with APS.[provided by RefSeq, Dec 2019].