APOA5
Sign in to saveAlso known as APOAV, RAP3, apolipoprotein A5
Apolipoprotein A-V is a protein that in humans is encoded by the APOA5 gene on chromosome 11. It is significantly expressed in liver. The protein encoded by this gene is an apolipoprotein and an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of several lipoprotein fractions including VLDL, HDL, chylomicrons. It is believed that apoA-V affects lipoprotein metabolism by interacting with LDL-R gene family receptors. Considering its association with lipoprotein levels, APOA5 is implicated in metabolic syndrome. The APOA5 gene
Gene data
APOA5- Name
- apolipoprotein A5
- Type
- protein-coding
- Position
- 116,789,014–116,793,026 (−)
- Aliases
- APOAV, RAP3
- Ensembl
- ENSG00000110243
- RefSeq RNA
- NM_001166598.2, NM_001371904.1, NM_052968.5
- RefSeq protein
- NP_001160070.1, NP_001358833.1, NP_443200.2
The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Oct 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
apolipoprotein A5
- Symbol
- APOA5
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:116,789,014-116,793,026
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- found in taxon
- Homo sapiens
- HomoloGene ID
- 14197
- exact match
- identifiers.org/ncbigene/116519
- chromosome
- human chromosome 11
- genomic start
- 116660083
- genomic end
- 116663136
- cytogenetic location
- 11q23.3
- expressed in
- myometrium
via Wikidata · CC0
~14 min read
Encyclopedic overview
21 sectionsContents
- Discovery
- Structure
- Gene
- Protein
- Tissue distribution
- Function
- Gene variability
- Clinical significance
- As a risk factor
- Plasma lipids and cardiovascular disease
- Myocardial infarction
- Clinical marker
- BMI, metabolic syndrome
- Nutri-, acti- and pharmacogenetic associations
- Other roles
- Interactive pathway map
- See also
- Notes
- References
- External links
- Further reading
Apolipoprotein A-V is a protein that in humans is encoded by the APOA5 gene on chromosome 11. It is significantly expressed in liver. The protein encoded by this gene is an apolipoprotein and an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of several lipoprotein fractions including VLDL, HDL, chylomicrons. It is believed that apoA-V affects lipoprotein metabolism by interacting with LDL-R gene family receptors. Considering its association with lipoprotein levels, APOA5 is implicated in metabolic syndrome. The APOA5 gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.
== Discovery ==
Excerpted from Wikipedia’s “APOA5” article, available under the CC BY-SA 4.0 licence.