LRP8

Also known as APOER2, HSZ75190, LRP-8, MCI1, low density lipoprotein receptor-related protein 8, LDL receptor related protein 8

cell surface receptor, part of the low-density lipoprotein receptor family

Gene data

LRP8

Name: LDL receptor related protein 8
Type: protein-coding
Position: 53,242,364–53,328,469 (−)
Aliases: APOER2, HSZ75190, LRP-8, MCI1
Ensembl: ENSG00000157193
RefSeq RNA: NM_001018054.3, NM_004631.5, NM_017522.5, NM_033300.4
RefSeq protein: NP_001018064.1, NP_004622.2, NP_059992.3, NP_150643.2

This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011].