APOC3

Name

apolipoprotein C3

Type

protein-coding

Position

116,827,019–116,833,343 (+)

Aliases

APOCIII, Apo-C3, ApoC-3

Ensembl

ENSG00000110245

RefSeq RNA

NM_000040.3

RefSeq protein

NP_000031.1

This gene encodes a protein component of triglyceride (TG)-rich lipoproteins (TRLs) including very low density lipoproteins (VLDL), high density lipoproteins (HDL) and chylomicrons. The encoded protein plays a role in role in the metabolism of these TRLs through multiple modes. This protein has been shown to promote the secretion of VLDL1, inhibit lipoprotein lipase enzyme activity, and delay catabolism of TRL remnants. Mutations in this gene are associated with low plasma triglyceride levels and reduced risk of ischemic cardiovascular disease, and hyperalphalipoproteinemia, which is characterized by elevated levels of high density lipoprotein (HDL) and HDL cholesterol in human patients. This gene and other related genes comprise an apolipoprotein gene cluster on chromosome 11. [provided by RefSeq, Sep 2017].

via MyGene.info

Gene · Ensembl

apolipoprotein C3

Symbol

APOC3

Biotype

Protein coding

Organism

Homo sapiens

Location

11:116,827,019-116,835,254

Strand

Forward (+)

Assembly

GRCh38

• Plozasiran (ARO-APOC3) for Severe Hypertriglyceridemia: The SHASTA-2 Randomized Clinical Trial.JAMA cardiology · 2024
• APOC3 siRNA and ASO therapy for dyslipidemia.Current opinion in endocrinology, diabetes, and obesity · 2024
• Targeting APOC3 with Olezarsen in Moderate Hypertriglyceridemia.The New England journal of medicine · 2025
• Plozasiran, an RNA Interference Agent Targeting APOC3, for Mixed Hyperlipidemia.The New England journal of medicine · 2024
• Joint Associations of APOC3 and LDL-C-Lowering Variants With the Risk of Coronary Heart Disease.JAMA cardiology · 2025

via PubMed

Wikidata facts

Image

APOC3.png

via Wikidata · CC0