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kinetochore
EntityQ908912· pop 28· linked from 119 articles

kinetochore

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Also known as GO:0000776, Kinetochores, condensed nuclear chromosome kinetochore, condensed chromosome kinetochore

300px|thumb|Image of kinetochores in pink

Research

7,286 papers

via PubMed

~30 min read

Encyclopedic overview

11 sections
Contents
  • Structure
  • In animal cells
  • Function
  • Chromosome anchoring to MTs in the mitotic spindle
  • Capturing MTs
  • Role of Ndc80 complex
  • Verification of kinetochore–MT anchoring
  • Spindle checkpoint activation
  • Force generation to propel chromosome movement
  • References
  • External links

300px|thumb|Image of kinetochores in pink

A kinetochore (, ) is a flared oblique-shaped protein structure associated with duplicated chromatids in eukaryotic cells where the spindle fibers, which can be thought of as the ropes pulling chromosomes apart, attach during cell division to pull sister chromatids apart. The kinetochore assembles on the centromere and links the chromosome to microtubule polymers from the mitotic spindle during mitosis and meiosis. The term kinetochore was first used in a footnote in a 1934 Cytology book by Lester W. Sharp and commonly accepted in 1936. Sharp's footnote reads: "The convenient term kinetochore (= movement place) has been suggested to the author by J. A. Moore", likely referring to John Alexander Moore who had joined Columbia University as a freshman in 1932.

Excerpted from Wikipedia’s “kinetochore” article, available under the CC BY-SA 4.0 licence.

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