CENPH
Sign in to saveAlso known as centromere protein H
Centromere protein H is a protein that in humans is encoded by the CENPH gene. It is involved in the assembly of kinetochore proteins, mitotic progression and chromosome segregation.
Gene data
CENPH- Name
- centromere protein H
- Type
- protein-coding
- Position
- 69,189,537–69,210,357 (+)
- Ensembl
- ENSG00000153044
- RefSeq RNA
- NM_022909.4
- RefSeq protein
- NP_075060.1
Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
centromere protein H
- Symbol
- CENPH
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:69,189,537-69,210,357
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~2 min read
Encyclopedic overview
5 sectionsContents
- Function
- Interactions
- References
- External links
- Further reading
Centromere protein H is a protein that in humans is encoded by the CENPH gene. It is involved in the assembly of kinetochore proteins, mitotic progression and chromosome segregation.
== Function ==
Excerpted from Wikipedia’s “CENPH” article, available under the CC BY-SA 4.0 licence.