CENPF

Also known as CENF, PRO1779, hcp-1, CILD31, STROMS, centromere protein F

Centromere protein F is a protein that in humans is encoded by the CENPF gene. It is involved in chromosome segregation during cell division. It also has a role in the orientation of microtubules to form cellular cilia.

Gene data

CENPF

Name: centromere protein F
Type: protein-coding
Position: 214,603,172–214,664,574 (+)
Aliases: CENF, CILD31, PRO1779, STROMS, hcp-1
Ensembl: ENSG00000117724
RefSeq RNA: NM_016343.4, XM_011509082.4, XM_017000086.3, XM_054333891.1, XM_054333892.1
RefSeq protein: NP_057427.3, XP_011507384.1, XP_016855575.1, XP_054189866.1, XP_054189867.1

This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

Article

6 sections

Contents

Function
Clinical significance
See also
References
External links
Further reading

== Function == CENPF is part of the nuclear matrix during the G2 phase of the cell cycle (the phase of rapid protein synthesis in preparation for mitosis). In late G2, the protein forms part of the kinetochore, a disc-shaped protein complex that allows the centromere of two sister chromatids to attach to microtubules (forming the spindle apparatus) in order for the microtubules to pull them apart in the process of dividing the cell. It remains part of the kinetochore through early anaphase (the chromosome-dividing phase). In late anaphase, CENPF localises to the spindle midzone, and in telophase (the cell-dividing phase) it localises to the intercellular bridge. It is thought to be subsequently degraded. Mutations in CENPF lead to impaired cell division during early development. Mitosis has been found to take longer when the gene is mutated.