TRIP13
Sign in to saveAlso known as 16E1BP, thyroid hormone receptor interactor 13, MVA3, OOMD9
TRIP13 is a mammalian gene that encodes the thyroid receptor-interacting protein 13. In budding yeast, the analog for TRIP13 is PCH2. TRIP13 is a member of the AAA+ ATPase family, a family known for mechanical forces derived from ATP hydrolase reactions. The TRIP13 gene has been shown to interact with a variety of proteins and implicated in a few diseases, notably interacting with the ligand binding domain of thyroid hormone receptors, and may play a role in early-stage non-small cell lung cancer. However, recent evidence implicates TRIP13 in various cell cycle phases, including meiosis G2/Pro
Gene data
TRIP13- Name
- thyroid hormone receptor interactor 13
- Type
- protein-coding
- Aliases
- 16E1BP, MVA3, OOMD9, OZEMA9
This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer. [provided by RefSeq, Oct 2009].
via MyGene.info
Gene · Ensembl
thyroid hormone receptor interactor 13
- Symbol
- TRIP13
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:892,849-919,357
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 3125
- exact match
- identifiers.org/ncbigene/9319
- genomic end
- 919472
- genomic start
- 892884
- cytogenetic location
- 5p15.33
Sources (4)
via Wikidata · CC0
~6 min read
Article
6 sectionsContents
- Structure
- Role in meiosis G2/prophase
- Role in spindle assembly checkpoint
- Implications in cancer
- References
- Further reading
TRIP13 is a mammalian gene that encodes the thyroid receptor-interacting protein 13. In budding yeast, the analog for TRIP13 is PCH2. TRIP13 is a member of the AAA+ ATPase family, a family known for mechanical forces derived from ATP hydrolase reactions. The TRIP13 gene has been shown to interact with a variety of proteins and implicated in a few diseases, notably interacting with the ligand binding domain of thyroid hormone receptors, and may play a role in early-stage non-small cell lung cancer. However, recent evidence implicates TRIP13 in various cell cycle phases, including meiosis G2/Prophase and during the Spindle Assembly checkpoint (SAC). Evidence shows regulation to occur through the HORMA domains, including Hop1, Rev7, and Mad2. Of note, Mad2's involvement in the SAC is shown to be affected by TRIP13 Due to TRIP13's role in cell cycle arrest and progression, it may present opportunity as a therapeutic candidate for cancers.
== Structure ==