DLGAP5

Also known as DLG7, HURP, discs large homolog associated protein 5, DLG associated protein 5

Disks large-associated protein 5 (DAP-5) also known as discs large homolog 7 (DLG7) or hepatoma up-regulated protein (HURP) is a protein that in humans is encoded by the DLGAP5 gene.

Gene data

DLGAP5

Name: DLG associated protein 5
Type: protein-coding
Position: 55,148,110–55,191,608 (−)
Aliases: DLG7, HURP
Ensembl: ENSG00000126787
RefSeq RNA: NM_001146015.2, NM_014750.5, XM_017021840.3, XM_047432016.1, XM_054377137.1
RefSeq protein: NP_001139487.1, NP_055565.3, XP_016877329.1, XP_047287972.1, XP_054233112.1

Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including centrosome localization; kinetochore assembly; and mitotic spindle organization. Located in several cellular components, including centrosome; cytosol; and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Biological process

mitotic spindle organization chromosome segregation

Article

3 sections

Contents

References
Further reading
External links

Disks large-associated protein 5 (DAP-5) also known as discs large homolog 7 (DLG7) or hepatoma up-regulated protein (HURP) is a protein that in humans is encoded by the DLGAP5 gene.

DLG7 is a kinetochore protein that stabilizes microtubules in vicinity of chromosomes. DLG7 controls spindle dynamics, promotes interkinetochore tension and efficient kinetochore capture. DGL7 is a part of Ran-dependent complex. Stabilization of DGL7 in cell occurs due to phosphorylation by Aurora A kinase. Expression of DGL7 is found in cancer and stem cells.