PDCD5

Also known as TFAR19, programmed cell death 5

Programmed cell death protein 5 is a protein, originally identified as an apoptosis-accelerating protein, that in humans is encoded by the PDCD5 gene.

Gene data

PDCD5

Name: programmed cell death 5
Type: protein-coding
Position: 32,581,188–32,587,453 (+)
Aliases: TFAR19
Ensembl: ENSG00000105185
RefSeq RNA: NM_004708.4, XM_005259392.6, XM_054322581.1
RefSeq protein: NP_004699.1, XP_005259449.1, XP_054178556.1

This gene encodes a protein that is upregulated during apoptosis where it translocates rapidly from the cytoplasm to the nucleus. The encoded protein may be an important regulator of K(lysine) acetyltransferase 5 (a protein involved in transcription, DNA damage response and cell cycle control) by inhibiting its proteasome-dependent degradation. Pseudogenes have been identified on chromosomes 5 and 12 [provided by RefSeq, Dec 2010].

Gene Ontology

Biological process

T cell activation regulation of apoptotic process positive regulation of apoptotic process cellular response to transforming growth factor beta stimulus positive regulation of signal transduction by p53 class mediator positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator negative regulation of protein folding

Molecular function

DNA binding protein binding heparin binding acetyltransferase activator activity beta-tubulin binding protein sequestering activity

Cellular component

nucleus nucleus cytoplasm cytosol extracellular exosome

via MyGene.info

Gene · Ensembl

programmed cell death 5

Symbol: PDCD5
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:32,581,062-32,587,453
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein PDCD5 PDB 2cru.png

Show 5 more facts

HomoloGene ID: 10506
exact match: identifiers.org/ncbigene/9141
genomic start: 32581190
genomic end: 32587453
cytogenetic location: 19q13.11

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Further reading

Programmed cell death protein 5 is a protein, originally identified as an apoptosis-accelerating protein, that in humans is encoded by the PDCD5 gene.

This gene encodes a protein expressed in tumor cells during apoptosis independent of the apoptosis-inducing stimuli. Prior to apoptosis induction, this gene product is distributed in both the nucleus and cytoplasm.