PDCD5

Also known as TFAR19, programmed cell death 5

Programmed cell death protein 5 is a protein, originally identified as an apoptosis-accelerating protein, that in humans is encoded by the PDCD5 gene.

Gene data

PDCD5

Name: programmed cell death 5
Type: protein-coding
Position: 32,581,188–32,587,453 (+)
Aliases: TFAR19
Ensembl: ENSG00000105185
RefSeq RNA: NM_004708.4, XM_005259392.6, XM_054322581.1
RefSeq protein: NP_004699.1, XP_005259449.1, XP_054178556.1

This gene encodes a protein that is upregulated during apoptosis where it translocates rapidly from the cytoplasm to the nucleus. The encoded protein may be an important regulator of K(lysine) acetyltransferase 5 (a protein involved in transcription, DNA damage response and cell cycle control) by inhibiting its proteasome-dependent degradation. Pseudogenes have been identified on chromosomes 5 and 12 [provided by RefSeq, Dec 2010].

Gene Ontology

Biological process

T cell activation regulation of apoptotic process

Article

2 sections

Contents

References
Further reading

Programmed cell death protein 5 is a protein, originally identified as an apoptosis-accelerating protein, that in humans is encoded by the PDCD5 gene.

This gene encodes a protein expressed in tumor cells during apoptosis independent of the apoptosis-inducing stimuli. Prior to apoptosis induction, this gene product is distributed in both the nucleus and cytoplasm.