PDCD6IP

Also known as AIP1, ALIX, DRIP4, HP95, programmed cell death 6 interacting protein

Programmed cell death 6-interacting protein also known as ALIX is a protein that in humans is encoded by the PDCD6IP gene.

Gene data

PDCD6IP

Name: programmed cell death 6 interacting protein
Type: protein-coding
Aliases: AIP1, ALIX, DRIP4, HP95, MCPH29

This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012].

via MyGene.info

Gene · Ensembl

programmed cell death 6 interacting protein

Symbol: PDCD6IP
Biotype: Protein coding
Organism: Homo sapiens
Location: 3:33,798,318-33,869,707
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein PDCD6IP PDB 2oev.png

Show 5 more facts

HomoloGene ID: 22614
exact match: identifiers.org/ncbigene/10015
genomic end: 33911194
genomic start: 33798571
cytogenetic location: 3p22.3

Sources (4)

via Wikidata · CC0

~1 min read

Article

5 sections

Contents

Function
Interactions
References
Further reading
External links

Programmed cell death 6-interacting protein also known as ALIX is a protein that in humans is encoded by the PDCD6IP gene.

This gene encodes a protein thought to participate in programmed cell death. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization which may be partly responsible for the protection against cell death.