CDH6

Also known as CAD6, KCAD, cadherin 6

Cadherin-6 is a protein that in humans is encoded by the CDH6 gene.

Gene data

CDH6

Name: cadherin 6
Type: protein-coding
Position: 31,193,686–31,329,146 (+)
Aliases: CAD6, KCAD
Ensembl: ENSG00000113361
RefSeq RNA: NM_001362435.2, NM_004932.4, XM_011513921.4, XM_047416591.1, XM_054351375.1
RefSeq protein: NP_001349364.1, NP_004923.1, XP_011512223.1, XP_047272547.1, XP_054207350.1

This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. [provided by RefSeq, May 2011].

Gene Ontology

Biological process

cell morphogenesis cell-cell junction assembly cell adhesion cell adhesion homophilic cell-cell adhesion calcium-dependent cell-cell adhesion cell migration adherens junction organization

Molecular function

calcium ion binding beta-catenin binding cadherin binding

Cellular component

plasma membrane plasma membrane plasma membrane adherens junction membrane catenin complex cell junction synapse

Pathways

Cell-Cell communication Adherens junctions interactions Cell-cell junction organization Cell junction organization Neural Crest Differentiation Ectoderm Differentiation TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition Pathways Regulating Hippo Signaling Hippo-Merlin Signaling Dysregulation

via MyGene.info

Gene · Ensembl

cadherin 6

Symbol: CDH6
Biotype: Protein coding
Organism: Homo sapiens
Location: 5:31,193,679-31,329,146
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 21027
exact match: identifiers.org/ncbigene/1004
genomic end: 31329253
genomic start: 31193686
cytogenetic location: 5p13.3

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Cadherin-6 is a protein that in humans is encoded by the CDH6 gene.

This gene encodes a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell–cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell–cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of this gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion.