CDH6

Also known as CAD6, KCAD, cadherin 6

Cadherin-6 is a protein that in humans is encoded by the CDH6 gene.

Gene data

CDH6

Name: cadherin 6
Type: protein-coding
Position: 31,193,686–31,329,146 (+)
Aliases: CAD6, KCAD
Ensembl: ENSG00000113361
RefSeq RNA: NM_001362435.2, NM_004932.4, XM_011513921.4, XM_047416591.1, XM_054351375.1
RefSeq protein: NP_001349364.1, NP_004923.1, XP_011512223.1, XP_047272547.1, XP_054207350.1

This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. [provided by RefSeq, May 2011].

Gene Ontology

Biological process

cell morphogenesis cell-cell junction assembly

Article

3 sections

Contents

References
Further reading
External links

Cadherin-6 is a protein that in humans is encoded by the CDH6 gene.

This gene encodes a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell–cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell–cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of this gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion.