DSG3
Sign in to saveAlso known as CDHF6, PVA, desmoglein 3, ABOLM
Desmoglein-3 is a protein that in humans is encoded by the DSG3 gene. In the skin epidermis Desmoglein-3 is expressed in the basal lower layers of the epidermis, and dominates in terms of expression on mucosal surfaces compared to Desmoglein-1.
Gene data
DSG3- Name
- desmoglein 3
- Type
- protein-coding
- Position
- 31,447,741–31,478,702 (+)
- Aliases
- ABOLM, CDHF6, PVA
- Ensembl
- ENSG00000134757
- RefSeq RNA
- NM_001944.3, XM_011525850.3, XM_054318238.1
- RefSeq protein
- NP_001935.2, XP_011524152.1, XP_054174213.1
This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. The encoded protein has been identified as the autoantigen of the autoimmune blistering disease pemphigus vulgaris. [provided by RefSeq, Jan 2016].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
desmoglein 3
- Symbol
- DSG3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 18:31,447,741-31,478,702
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- DSG3 protein.png
Show 5 more facts
- HomoloGene ID
- 55513
- exact match
- identifiers.org/ncbigene/1830
- genomic end
- 29058665
- genomic start
- 31447741
- cytogenetic location
- 18q12.1
Sources (8)
via Wikidata · CC0
~2 min read
Article
6 sectionsContents
- Function
- Pathogenicity
- Interactions
- See also
- References
- Further reading
Desmoglein-3 is a protein that in humans is encoded by the DSG3 gene. In the skin epidermis Desmoglein-3 is expressed in the basal lower layers of the epidermis, and dominates in terms of expression on mucosal surfaces compared to Desmoglein-1.
== Function ==