CDH4
Sign in to saveAlso known as CAD4, R-CAD, RCAD, cadherin 4
Cadherin-4 is a protein that in humans is encoded by the CDH4 gene.
In the Vinony graph
Within Vinony's link graph, CDH4 is referenced by 108 other articles, and connects out to PubMed, human chromosome 20 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 20.
Its subject is documented across 5 Wikipedia language editions.
Gene data
CDH4- Name
- cadherin 4
- Type
- protein-coding
- Position
- 61,252,208–61,940,617 (+)
- Aliases
- CAD4, R-CAD, RCAD
- Ensembl
- ENSG00000179242
- RefSeq RNA
- NM_001252338.2, NM_001252339.3, NM_001794.5, XM_047439812.1, XM_047439813.1
- RefSeq protein
- NP_001239267.1, NP_001239268.1, NP_001785.2, XP_047295768.1, XP_047295769.1
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
cadherin 4
- Symbol
- CDH4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr HSCHR20_1_CTG2:8,605-54,269
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 9 more facts
- HomoloGene ID
- 48044
- chromosome
- human chromosome 20
- genetic association
- obesity
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/1002
- genomic start
- 61252261
- genomic end
- 60515673
- cytogenetic location
- 20q13.33
- expressed in
- prefrontal cortex
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Interactions
- References
- Further reading
- External links
Cadherin-4 is a protein that in humans is encoded by the CDH4 gene.
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization.
Excerpted from Wikipedia’s “CDH4” article, available under the CC BY-SA 4.0 licence.