PALLD

Also known as CGI-151, CGI151, MYN, PNCA1, SIH002, palladin, cytoskeletal associated protein

Palladin is a protein that in humans is encoded by the PALLD gene. Palladin is a component of actin-containing microfilaments that control cell shape, adhesion, and contraction.

Gene data

PALLD

Name: palladin, cytoskeletal associated protein
Type: protein-coding
Position: 168,497,052–168,928,457 (+)
Aliases: CGI-151, CGI151, MYN, PNCA1, SIH002
Ensembl: ENSG00000129116
RefSeq RNA: NM_001166108.2, NM_001166109.2, NM_001166110.2, NM_001367567.1, NM_001367568.1
RefSeq protein: NP_001159580.1, NP_001159581.1, NP_001159582.1, NP_001354496.1, NP_001354497.1

This gene encodes a cytoskeletal protein that is required for organizing the actin cytoskeleton. The protein is a component of actin-containing microfilaments, and it is involved in the control of cell shape, adhesion, and contraction. Polymorphisms in this gene are associated with a susceptibility to pancreatic cancer type 1, and also with a risk for myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].

Gene Ontology

Biological process

cytoskeleton organization homophilic cell-cell adhesion axon guidance cell migration actin cytoskeleton organization dendrite self-avoidance

Molecular function

protein binding muscle alpha-actinin binding muscle alpha-actinin binding cell-cell adhesion mediator activity

Cellular component

stress fiber stress fiber ruffle podosome nucleus cytosol cytoskeleton actin filament

via MyGene.info

Gene · Ensembl

palladin, cytoskeletal associated protein

Symbol: PALLD
Biotype: Protein coding
Organism: Homo sapiens
Location: 4:168,497,038-168,928,610
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein PALLD PDB 2dm2.png

Show 5 more facts

HomoloGene ID: 75052
exact match: identifiers.org/ncbigene/23022
genomic end: 169849608
genomic start: 168497052
cytogenetic location: 4q32.3

Sources (3)

via Wikidata · CC0

~3 min read

Article

8 sections

Contents

Discovery
Isoforms
Function
Disease linkage
Interactions
References
Further reading
External links

Palladin is a protein that in humans is encoded by the PALLD gene. Palladin is a component of actin-containing microfilaments that control cell shape, adhesion, and contraction.

== Discovery ==