Also known as CVIL, CVL, HEL-S-105, VIL2, Ezrin
Ezrin, also known as cytovillin or villin-2, is a protein that in humans is encoded by the EZR gene.
Gene data
EZR- Name
- ezrin
- Type
- protein-coding
- Position
- 158,765,738–158,819,418 (−)
- Aliases
- CVIL, CVL, HEL-S-105, VIL2
- Ensembl
- ENSG00000092820
- RefSeq RNA
- NM_001111077.2, NM_003379.5, XM_011536110.2, XM_054356313.1
- RefSeq protein
- NP_001104547.1, NP_003370.2, XP_011534412.1, XP_054212288.1
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
ezrin
- Symbol
- EZR
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:158,765,738-158,819,418
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein VIL2 PDB 1ni2.png
Show 6 more facts
- HomoloGene ID
- 55740
- exact match
- identifiers.org/ncbigene/7430
- genomic end
- 158819368
- genomic start
- 159186773
- cytogenetic location
- 6q25.3
- Commons category
- Ezrin
via Wikidata · CC0
~2 min read
Article
5 sectionsContents
- Structure
- Function
- Interactions
- References
- Further reading
Ezrin, also known as cytovillin or villin-2, is a protein that in humans is encoded by the EZR gene.
== Structure ==