sialophorin
Sign in to saveAlso known as SPN, leukosialin, GALGP, sialophorin (gpL115, leukosialin, CD43), galactoglycoprotein, leukocyte sialoglycoprotein, SPN protein, human
Leukosialin also known as sialophorin or CD43 (cluster of differentiation 43) is a transmembrane cell surface protein that in humans is encoded by the SPN (sialophorin) gene.
In the Vinony graph
Vinony's link graph records 442 inbound references to sialophorin, and connects out to mucin, PubMed and T-lymphocytes.
It sits within the topics Clusters of differentiation, Genes on human chromosome 16 and Mucins.
Vinony links it to 7 Wikipedia language editions.
Protein · UniProt
Leukosialin
- Gene
- SPN
- Organism
- Homo sapiens (Human)
- Length
- 400 aa
- Molecular mass
- 40,322 Da
- Evidence
- 1: Evidence at protein level
Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cel…
Swiss-Prot (reviewed) · via UniProt
Research
837 papers- Sialophorin (CD43) and the Wiskott-Aldrich syndrome.Immunodeficiency reviews · 1990
- CD43 (sialophorin) is involved in the induction of extracellular matrix remodeling and angiogenesis by lung cancer cells.Journal of cellular physiology · 2021
- Sialylated CD43 forms a glyco-immune barrier that restrains antileukemic immunity.Science (New York, N.Y.) · 2026
- Sialophorin, a surface sialoglycoprotein defective in the Wiskott-Aldrich syndrome, is involved in human T lymphocyte proliferation.The Journal of experimental medicine · 1987
- Expression on blood cells of sialophorin, the surface glycoprotein that is defective in Wiskott-Aldrich syndrome.Blood · 1987
via PubMed
Wikidata facts
- Instance of
- protein
Show 4 more facts
- cell component
- extracellular exosome
- biological process
- signal transduction
- found in taxon
- Homo sapiens
- exact match
- www.ncbi.nlm.nih.gov/protein/P16150
via Wikidata · CC0
~1 min read
Encyclopedic overview
6 sectionsContents
- Function
- Clinical significance
- Interactions
- References
- Further reading
- External links
Leukosialin also known as sialophorin or CD43 (cluster of differentiation 43) is a transmembrane cell surface protein that in humans is encoded by the SPN (sialophorin) gene.
== Function ==
Excerpted from Wikipedia’s “sialophorin” article, available under the CC BY-SA 4.0 licence.